Volume-Stabilized Intravascular Microbubbles for Circulatory Transport of Oxygen and Carbon Dioxide: A Field-Usable Concept
Abstract
Intravascular microbubbles generated by i.v. infusion of a 2% dodecafluoropentane emulsion (DDFPe) transports physiologically significant amounts of oxygen in oxygen breathing rats (1). The present study explores the question whether DDFPe treatment can sustain life during air breathing in severely erythrocyte depleted pigs. Anesthetized pigs were bled while given volume replacement with 6% dextran in lactated Ringer's solution. Artificial ventilation and/or oxygen admixture (<4%) to the inspired air maintained PaO2 in the normoxic range (90-110 mm Hg) . Control animals (n=6) received emulsion blank in addition to the plasma expander. They died at a hemoglobin level of 3.0 g/100 ml. The experimental animals received 0.7 ml DDFPe/kg body weight in an i.v. infusion lasting for ^190 min of the 260 min long exsanguination period. These animals were observed for more than one hour at hemoglobin levels averaging 2.1 g/100 ml. They retained a normal PVO2 and acid-base status indicating adequate tissue oxygenation and arterial blood pressures remained well above shock level. We conclude that DDFP derived microbubbles hold promise as a very effective erythrocyte substitute for circulatory oxygen transport in situations such as combat casualty care. Hence, the treatment should be tested in a circulatory shock model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADB274844
Entities
People
- Claes Lundgren
- Guri Bergoe
- Ingvald Tyssebotn
Organizations
- University at Buffalo