Imaging Angiogenesis In Vivo: 'Immunospecific' Magnetic Resonance Imaging of Breast Tumors Using Antibody-Coated Magnetic Particles

Abstract

The purpose of this research is to develop a non-invasive observation of angiogenesis through the design and validation of MRI pulse sequences and novel contrast agents and to use this agent to monitor angiogenesis in vivo over time during tumor development. This is being achieved by the following: 1) Optimization of MR pulse sequence technology for the relative assessment of tissue iron concentrations based on the quantitative evaluation of T2 and T2* weighted images. (2) Development of novel, highly specific iron oxide based, magnetic resonance contrast agents to be used for targeting receptors and/or macrophage populations associated with tumor cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADB275535

Entities

People

  • Paula J. Gareau

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Angiogenesis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Computer Programs
  • Computers
  • Health Services
  • Macrophages
  • Magnetic Resonance
  • Metal Oxide Nanoparticles
  • Neoplasms
  • Particles
  • Resonance
  • Spectra
  • Test And Evaluation

Fields of Study

  • Medicine
  • Physics

Readers

  • Immunology and Pathology
  • Medical Imaging.
  • Molecular and Cellular Biochemistry