Gene Profiling of Protease Induced Genes in Breast Cancer

Abstract

The thrombin receptor (protease activated receptor 1, PAR-i) is not detectable in non-invasive ductal carcinoma in situ, but is highly upregulated in invasive breast cancer. In breast cancer cell lines, PAR-i is expressed in more metastatic cells, conferring sensitivity to thrombin. Gene profiling of breast cancer cells stimulated with thrombin or a direct PAR-i agonist demonstrate the upregulation of genes that support cell survival and that regulate angiogenesis. Large scale gene profiling for expression tagged genes (ests) indicate additional downstream gene targets of thrombin signaling. These genes may prove of relevance for breast cancer progression.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2001
Accession Number
ADB277942

Entities

People

  • Wolfram Ruf

Organizations

  • Scripps Research

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Biological Factors
  • Biomedical Research
  • Blood
  • Blood Coagulation Factors
  • Blood Vessels
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computer Programs
  • Dna Microarrays
  • Mammary Glands
  • Neoplasms
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.