Study of the Regulation of Telomere Replication by Characterizing the Cdc-13p Pathway in Yeast

Abstract

Telomeres are repeated double stranded DNA sequences at chromosome ends. Replication of telomeres requires telomerase. Recent data suggest telomere length maintenance might be involved in the origin or progression of cancer and aging. Understanding of telomere replication could offer new targets for drug screen. The conservation of telomerase and telomere structure has made yeast a good system to study the problem. An essential yeast telomere binding protein Cdc13p appears to play a key regulatory role in telomere replication. This study showed that Pol alpha is involved in telomere replication. Cdc13p regulates telomere length during telomere replication by interacting with both telomerase and Pol alpha. This study also identified Cdc13p and yeast PCNA interaction. This interaction might be%important for limiting C-strand degradation, process necessary for telomere replication and can kill cells when not limited. Other Cdc13p interacting proteins were also identified. Further studies are in progress.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2002
Accession Number
ADB279633

Entities

People

  • Qi Haiyan

Organizations

  • Princeton University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Carrier Proteins
  • Cells
  • Cellular Structures
  • Chemistry
  • Chromosome Structures
  • Computer Programs
  • Dna Sequence Analysis
  • Eukaryotes
  • Fungi
  • Genetic Code
  • Genetic Structures
  • Genetics
  • Molecular Dynamics

Fields of Study

  • Biology

Readers

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  • Molecular Biology and Genetics