Identification of Estrogen Receptors and Their Role in Breast Cancer

Abstract

Breast cancer is the most common form of cancers among women. The experiments described are testing the feasibility of an in vitro assay, based on dynamic alteration in gene expression of specific genes, to predict the response to drug treatment. From the previously identified set of genes, two genes PDZK1 and GREB1 were confirmed to be estrogen-responsive. We now test whether we can more accurately determine the response of tumor to the treatment with tamoxifen, an antiestrogenic drug, by analyzing the changes in expression of GREB1 and PDZK1 upon treatment with tamoxifen.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADB283063

Entities

People

  • Nandita Sharma

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkenes
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Computer Programs
  • Contractors
  • Estrogens
  • Gene Expression
  • Government (Foreign)
  • Government Procurement
  • Governments
  • Hormones
  • Neoplasms
  • Sex Hormones

Readers

  • Breast cancer cell signaling and growth regulation.
  • Computational Modeling and Simulation