Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging

Abstract

The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measured by a completely non-invasive MRI method. This hypothesis is being tested by: 1) The design and construction of ultra-high gradient coils for MRI. 2) The implementation of advanced MRI pulse sequences for mapping of microvascular parameters 3) The correlation of MRI-derived vascular parameters (diffusion and perfusion) with histological parameters (tumor grade and microvessel density) in an animal model of human breast cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADB283518

Entities

People

  • Brian K. Rutt
  • Paula J. Gareau

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Blood Vessels
  • Breast Cancer
  • Cancer
  • Circuit Boards
  • Computer Programs
  • Computers
  • Construction
  • Fabrication
  • Health Services
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Neoplasms
  • Neuroimaging
  • Resonance
  • Three Dimensional

Fields of Study

  • Medicine
  • Physics

Readers

  • Medical Imaging.