Identification of Cellular and Molecular Markers of Prostate Cancer Progression in Racial-Ethnic Minorities
Abstract
Our specific aims were to examine men with prostate cancer from 4 different racial-ethnic groups (African-American, Latino, Asian and Caucasians men) to determine the prevalence of molecular and cellular changes that may play a role in prostate tumor progression, particularly invasion and metastasis. The assessment of the tissue samples includes markers that are involved in the following pathways: a) cell cycle regulation, b)apoptosis, d) invasion and metastasis, and hormonal regulation. Our work in the development of Spectral Imaging techniques will enable us to assess many more markers on the tissue available to us for this project than we had anticipated at the onset of this study. This will greatly enhance our understanding of the molecular and cellular changes in these tumor samples. The results of the analysis of these markers are being assessed to determine the relationship between the changes in these key biological pathways and race/ethnicity, age - and the intermediate markers of disease progression (tumor stage and Gleason grade). Finally, after sufficient follow-up time as elapsed, these changes will be related to clinical outcome (recurrence and survival) within and between the racial/ethnic groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADB283788
Entities
People
- Richard J. Cote
Organizations
- University of Southern California