MEKK1-JNK/p38 Pathways and the Resistance of Breast Cancer to Tamoxifen
Abstract
The main purpose of the conceptual grant is to provide seed money to explore an idea that may generate preliminary data for a research proposal of a more traditional grant. Our studies far exceeded this goal. As planned in the proposal, the research by the one-year funding focused on determining whether MEKK1-p38/JNK activity is increased in tamoxifen-resistant breast cancer cells. Our studies generated positive data that showed that both JNK and p38 activity is increased in breast cancer cells that become tamoxifen resistant. We also obtained data showing that the activation of the estrogen receptor by MEKK1 changed during the development of tamoxifen resistance of MCF-7 breast cancer cells. Our studies have resulted in one publication in a first class journal, an idea grant proposal submitted to FY02 DOD Breast Cancer Program and an abstract submitted to the Era of Hope meeting sponsored by DOD Breast Cancer Program.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADB285699
Entities
People
- Wenlong Bai
Organizations
- United States Army Medical Research and Development Command