Novel Vector System for Breast Cancer Therapy

Abstract

The funds from this proposal have been used to develop a novel, sustained-release delivery system for tumor necrosis factor alpha (TNF alpha) . Coacervate microspheres were made to contain TNF alpha that was released over 3 days. Efficacy testing by administering a single intratumoral dose of the sustained release preparation showed that it was superior to free-TNF alpha as either a stand-alone therapy, or in combination with other anti-neoplastic modalities. Additional studies described within suggest that this formulation could also be used as a means of targeting other anti-neoplastic modalities into tumors masses.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADB285735

Entities

People

  • Robert I. Garver Jr.

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Albumins
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Computer Programs
  • Contractors
  • Government (Foreign)
  • Government Procurement
  • Governments
  • Infection
  • Medical Personnel
  • Microspheres
  • Neoplasms
  • Proteins
  • Radiation
  • Therapy

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.