Role of Daxx in Apoptosis

Abstract

Control of the activation of apoptosis is important in protection against cancer. PML oncogenic domains (PODs) are subnuclear macromolecular complexes that play a critical role in the regulation of apoptosis. Daxx and PML, two pro-apoptotic proteins are found in PODs, along with at least a dozen or so other proteins. The mechanism by which PODs modulate apoptosis is poorly understood. Here we examine the localization of various components of the apoptosis pathway and find co-localization of certain key pro-apoptotic proteins in the PODs. This work suggests a model on how PODs may initiate apoptosis, and may help identify new approaches to modulate apoptosis for cancer therapy.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADB285832

Entities

People

  • Xiaolu Yang

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Apoptosis
  • Aspartic Acid
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Computer Programs
  • Contractors
  • Electronic Mail
  • Explosives Initiators
  • Government (Foreign)
  • Government Procurement
  • Governments
  • Instructions
  • Neoplasms

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Structural Health Monitoring of Composite Structures.