Risk for Sporadic Breast Cancer in Ataxia Telangiectasia Heterozygotes
Abstract
Purpose & scope: The discovery of p73, a gene that in experimental conditions behaves like p53, requires us to determine what role it plays in breast cancer, whether a crosstalk exists between p73 and p53 actions and to delineate the differences and similarities between these two genes concerning their biological role and signaling pathways. Our understanding of p53's role in breast cancer has been made hazier again by the advent of p73's discovery. An additional challenge derives from the fact that the TP73 gene in principle can produce two diametrically opposed classes of protein products full length forms and N-terminally truncated forms (that are missing the transactivation domain). Therefore, certain p73 isoforms could be dominant negative over p53 in heterocyclic interactions. Conversely, it has already been shown that p73's transactivation and apoptotic function is inhibited by tumor derived p53 mutants.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADB285885
Entities
People
- Ute M. Moll
Organizations
- State University of New York