Genetic Induction of Cytolytic Susceptibility in Breast Cancer Cells
Abstract
These studies are based upon our observation that the adenoviral ElA oncogene can convert highly cytolytic-resistant human tumor cells into cells that are highly susceptible to cytolysis triggered by a variety of immunological and chemical injuries. Observations made using mouse NlH-3T3 cells were translated to human breast cancer cells and other types of human tumor cells. This comparative analysis revealed that there are basic cellular traits controlled by BlA that are common among species and diverse cell types, Studies of the regulatory control pathways through which ElA-induced phenotypic conversion of human tumor cells is mediated were complemented by studies of differential gene expression. Studies of these molecular mechanisms were used as a basis for comparisons with in vivo studies of innate immunity-mediated and chemotherapy- induced rejection of ElA-expressing human tumor cells in vivo,
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADB285914
Entities
People
- James L. Cook
Organizations
- University of Chicago