Immune Response in Breast Cancer Sentinel Nodes

Abstract

Sentinel lymph node (SLN) biopsy allows identification of the first-draining lymph node from the site of primary tumors, Identification of tumor in these nodes predicts the metastatic potential of tumors. We tested the hypothesis that SLNs are the primary site of antigen specific T cell activation. And, the activation state of dendritic cells (DC) in SLNs is predictive of the immune status of tumors. Paraffin embedded SLNs from breast cancer patients were analyzed by immunohistochemistry to determine the maturation state of DC. Our results demonstrated that tumor-free SLNs contained higher numbers of mature CD83+ DC compared to tumor-containing SLNs (p=0.0 1) suggesting that an active immune response was occurring in these nodes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADB286137

Entities

People

  • Nancy J. Poindexter

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkanes
  • Biomedical Research
  • Biopsy
  • Breast Cancer
  • Cancer
  • Cells
  • Governments
  • Identification
  • Immunohistochemistry
  • Institutional Review Board
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Neoplasms

Fields of Study

  • Medicine

Readers

  • Battery Technology and Engineering
  • Immunology
  • Oncology and Biomarker-Based Cancer Detection.