Can Radiography Be Used to Exclude Negative Margins in Breast Cancer Specimens?
Abstract
Achieving tumor-free margins is an important clinical goal in breast conservation surgery for the treatment of breast cancer. This prospective observational study was designed to answer: can radiography be used to exclude negative margins in breast cancer specimens? Ninety-seven cancers in 95 patients were included in this study. Pathology was used as the gold standard in specimen analysis, each containing 6 (superior, inferior, lateral, medial, anterior, posterior) margins. Of the 5B2 specimens, there were 8 true positive, 463 true negative, 91 false negative, and 20 false positive margins. The following performance parameters were calculated: sensitivity 8%, specificity 96%, accuracy 81%. Overall, specimen radiography cannot be reliably used to diagnose positive margins, nor can it be used to exclude negative margins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADB286266
Entities
People
- Jessica Leung
Organizations
- Brigham and Women's Hospital