Vitamin D Receptor and Mammary Tumorigenesis
Abstract
In these studies, we have tested whether VDR ablation enhances sensitivity to oncogenic transformation, using the MMTV-neu transgenic mouse model of breast cancer Our studies involved crossing VDRKO mice with MMTV neu mice and monitoring tumor development and mammary gland morphology over time. Tumor development in the bigenic mice was slowed due to the influence of the C57BL6 genetic background, which is known for resistance to mammary tumorigenesis. At 15 months of age tumor development was less than 40% in bigenic mice, compared to 100% incidence in parental MMTV-neu mice at 8.5 months of age. Histological assessment of MMTV- neu primary tumors Indicated no consistent effects of VDR ablation on tumor morphology or neu expression VDR was highly expressed in neu driven mammary tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADB286365
Entities
People
- JoEllen Welsh
Organizations
- University of Notre Dame