Cell Cycle Regulation of Estrogen and Androgen Receptor
Abstract
It has been found that the androgen receptor is transcriptionally active in GO, and S-phases of the cell cycle but inactive at GI/S. This activity parallels protein levels although low protein alone is not responsible for loss of activity at GI/S since histones hyperacetylation rescues AR activity at this junction without increasing AR protein levels. It has been flirter shown that the histone deacetylase inhibitor TSA increases the transcriptional activity of the AR and that methoxyacetic acid synergizes with androgens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADB286395
Entities
People
- Elisabeth D. MartÃnez
Organizations
- George Washington University