Decorin, A Novel Anti-Tumor Agent That Blocks Breast Cancer Growth
Abstract
Decorin is a prototype member of a family of the so-called small leucine-rich proteoglycans. Recent evidence has shown that decorin down-regulates the growth of a variety of tumor cells including breast carcinoma cells. Specifically, we have previously shown that decorin blocks the ErbB2 activity and, therefore, we believe that this is the mechanism that is utilized by decorin-induced growth inhibition. In the past funded year, we have made an attempt to generate adeno-associated viral vector (AAV2) containing decorin. After several negative attempts, we were successful in generating an AAVl-decorin vector. In preliminary studies, we have shown that this vector is capable of transducing various tumor cell lines and generating decorin. We have requested and obtained a one-year, no cost extension to pursue the AAVl transduction experiments both in vitro and in vivo, in an animal model of orthotopic breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADB286736
Entities
People
- Renato V. Iozzo
Organizations
- Thomas Jefferson University