Detection and Prostate Cancer Utilizing Monoclonal Antibody J591 and Intraoperative Beta and Gamma Cameras
Abstract
The hypothesis of this project is that these novel cameras, applied during surgery on prostate cancer patients after being injected by radio labeled antibody J591, would detect small pieces of cancerous tissue that would otherwise remain undetected. According to our project, a group of prostate cancer patients who are scheduled for surgery, will be injected with radio labeled J591 mAb. Then our cameras will be used during surgery to locate any involved lymph node, or tissues at the margins of the resected prostate that may be infiltrated by cancer Also, we planned to use our flexible beta camera to locate the best site in transrectal biopsies using Y-90 - labeled mAb. According to our plan, the first year was devoted to development of the novel instrumentation for detection of prostate tumors. This task was successfully completed. The next eighteen months was devoted to testing and characterizing the devices in laboratory and improving them as needed. This task was also successfully completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2001
- Accession Number
- ADB286864
Entities
People
- Farhad Daghighian
- Steven M. Larson
Organizations
- Memorial Sloan Kettering Cancer Center