Mapping Genetic Modifiers of Mammary Tumor Susceptibility in BALB/c-Trp53+/-Mice
Abstract
The TP53 tumor suppressor gene is defective in the majority of sporadic breast cancers. Breast cancer is also the most frequent tumor type in women with Li-Fraumeni syndrome who inherit germline mutations in TP53. This suggests that p53 is fundamental to the growth regulation and prevention of tumors in the mammary epithelium. However, the incidence of mammary tumors in p53-deficient mice varies greatly among strains. We have undertaken the genetic mapping of modifiers of susceptibility by performing genetic crosses between mammary tumor-susceptible BALB/c-Trp53+/- mice and -resistant C57BL/6-Trp53+/- mice. Mammary tumor susceptibility was shown to segregate as a partially dominant trait with recessive-acting modifiers also detected.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADB287328
Entities
People
- D. J. Jerry
Organizations
- University of Massachusetts Amherst