Frequency-Domain Optical Mammogram
Abstract
This research project has involved the analysis of a clinical data set of frequency-domain optical mammograms (-150 patients) to maximize the effectiveness of this breast imaging modality for cancer detection and to guide further improvements of this technique. During the first year, we have computed edge-corrected optical mammograms (N-images) for the whole data set and obtained the corresponding ROC curve. During the second year, we have devised a new approach to tumor oximetry on the basis of spectral data, and we have started developing a second-derivative scheme of image processing. During the third year, we have finalized the second-derivative processing scheme and applied it to the whole set of clinical data. By combining the information provided by the second- derivative optical mammograms at one wavelength, and the oxygenation images computed from data at four wavelengths, we have obtained a new ROC curve that shows a significant improvement upon the ROC curve based on the N-images alone. In summary, we have completed our broad objectives: (1) maximize the clinically useful information extracted from the existing set of optical mammograms; (2) guide further developments of optical mammography by introducing a new approach to tumor oximetry.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADB287619
Entities
People
- Sergio Fantini
Organizations
- Tufts University