Chlorine. Median Lethal Concentration for Mice
Abstract
Object. The object of project A 10.4 is to collect "exact information on all those materials which may be indicated by the literature or by Chemical Warfare Service research as of possible interest for offensive chemical warfare agents." The object of the work described in this report was to determine the median lethal concentration of chlorine for white mice for an exposure period of 10 min and an observation period of 10 days. Directions regarding the work were given by the Chief, Chemical Warfare Service, as follows: "In order that a consistent basis of comparison can be maintained on all toxic compounds, it is desired that the median lethal concentration of chlorine for white mice on a 10-min exposure be obtained experimentally and in sufficient detail to be reliable and that this value be used as a standard." Results. Lethality to mice: Fifteen runs, using a 10-min exposure period and an observation period of 10 days, gave the following results (see table). Conclusions. The median lethal concentration of chlorine for selected white mice of the Carworth Farms' CF-1 strain, for an exposure period of 10 min and an observation period of 10 days, is 1.96 mg/l with an average deviation for 12 runs of + or - 0.19 mg/l. The majority of deaths were due to severe pulmonary edema.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 17, 1942
- Accession Number
- ADB955266
Entities
People
- F. P. Mcgrath
- R. L. Ferguson
- S. D. Silver