Chlorine. Median Lethal Concentration for Mice
Abstract
Object. The object of project A 10.4 is to collect exact information on all those materials which may be of possible interest for offensive chemical warfare agents as indicated either by the literature or by Chemical Warfare Service research. The object of the work described in this report was to determine the median lethal concentration of chlorine for white mice exposed for 10 minutes and observed for 10 days, in order to establish a standard with which similar data on other compounds may be compared. Results. Lethality to mice: Forty-nine runs, using a 10-min. exposure period and an observation period of 10 days, at concentrations from 0.73 to 3.30 mg./l, are reported in table 1, pages 5 and 6. Conclusions. 1. When the mice used were selected at random from miscellaneous lots, the m.l.c. of chlorine for an exposure period of 10 min. and an observation period of 10 days was 1.52 + or - an average deviation (for 20 runs of 20 mice each) of 0.19 mg./l. 2. When mice of carefully selected strain having a daily death rate for 10 days of 0.0% were used the m.l.c. of chlorine for an exposure period of 10 min. and an observation period of 10 days was 1.73 + or - an average deviation for 20 runs of 0.24 mgs/l. Recommendation. None, since further work is in progress and will be reported in E.A.T.R. 373.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 09, 1942
- Accession Number
- ADB955268
Entities
People
- F. P. Mcgrath
- S. D. Silver