Toxicity of Cyanogen Chloride to White Mice by Inhalation
Abstract
Object: The object of this work was to provide accurate data on the toxicity of cyanogen chloride to white mice. The redetermination of this value was carried out under Project A 3 as one of the tests of a compound believed to have possibilities for development as a quick-acting nonpersistent agent. The new data also constitute a revision of the data on this important compound given in the summary of mouse toxicity data now being prepared (E.A.T.R. 109) under Project A 10. Discussion: Mice exposed to a lethal concentration of cyanogen chloride for 10 min. show, first, a period of excitement followed by quiet, then another period of excitement of very short duration followed immediately by convulsions and complete collapse. The median lethal concentration on mice for 10-min. exposures is twice as high as the median lethal concentration for phosgene and four times as high as the median lethal concentration of hydrocyanic acid gas for the same length of exposure on mice. Conclusions: The experimental lethal concentration on mice for 10 min. exposures is between 0.75 mg/l and 0.781 mg/l using a 24-hr. observation period. The median lethal concentration, as read from the curve, for an exposure of 10 min. and an observation period of 24 hr. is 0.74 mg/l.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 03, 1933
- Accession Number
- ADB956466
Entities
People
- G. C. Armstrong