Toxicity of Phosgene to White Mice by Inhalation
Abstract
Object: The object of this work was to provide accurate and adequate data on the toxicity of phosgene by inhalation on white mice for a 10-min. exposure. Discussion: In the case of a gas like phosgene, where the chief cause of death is pulmonary edema, it is possible that deaths occurring within 48 hours after exposure are the best index of the toxicity of the gas. However, in order to provide all figures that may be required for comparison with other gases 5 day and 10 day mortalities are also given. Conclusions: The experimental lethal concentration for phosgene for a 10 minute exposure, and an observation period of 2 days (48 hours), can be placed at 0.375 to 0.377 mg/l. The experimental lethal concentration for phosgene for a 10 minute exposure, and an observational period of 5 days, is slightly greater than 0.366 mg/l. The median lethal concentration for phosgene, as read from the curve, for a 10 minute exposure (48 hour observation), is 0.375 mg/l.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 21, 1932
- Accession Number
- ADB956567
Entities
People
- W. Wells