Stable Free-Radical Structures.
Abstract
The patent application relates to a stable free-radical product, used to produce brain excitation in mammals when intravenously administered. The free-radical product is prepared from purified plasma proteins, pituitary peptides and other structures containing tyrosine or tryptophan by oxidation with a free-radical nitrosyl disulfonate product in alkaline solution under controlled conditions. Intravenous administration of the free-radical product into mammals causes a sudden electroencephalographic arousal accompanied by behavioral changes indicative of brain excitation. Illumination of the free-radical product by visible light prior to administration substantially enhances the arousal and brain excitation effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 03, 1973
- Accession Number
- ADD000690
Entities
People
- Byrel D. Polis
Organizations
- United States Department of the Navy