Magnetically-Localizable, Polymerized Lipid Vesticles and Method of Disrupting Same.
Abstract
It is an object of this invention to provide lipid vesicles that are stable in vivo to unintended physical and chemical disruption. A further object of this invention is to provided vesicles with polymerizable membranes. A further object of this invention is to provide vesicles that can carry aqueous solutions of therapeutic agents. A further object of this invention is to provide vesicles that can be immoblized at an in vivo target site by an external magnetic field. A further object of this invention is to control the rate of release of an encapulated therapeutic agent at the target site by oscillating the magnetic field. These and other objects are achieved by encapsulating therapeutic agents and ferromagnetic particles in a lipid vesicle formed using polymerizable lipids whichare subsequently polymerized to form a stable vesicle resistant to chemical and physical attack. The vesicles are attracted to the targeted site by an external magnetic field. Once localized at the target site, an oscillating magnetic field is used to destabilize the vesicle membrane resulting in controlled release of the therapeutic agent at the target site. This is a patent application.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 12, 1985
- Accession Number
- ADD011686
Entities
People
- E. L. Chang
Organizations
- United States Department of the Navy