Scaled-Up Production of Liposome-Encapsulated Hemoglobin.

Abstract

This invention relates to blood substitutes, and methods for their preparation. More particularly, it relates to a novel composition which can be administered to human patients as a blood substitute by transfusion. A method for making sterile liposome-encapsulated hemoglobin having an oxygen carrying capacity of 20 vol/%, a half life of 15-20 hours as measured in mice, with the liposome made from chloroform, HSPC, cholesterol, negatively charged DMPG and alpha-tocopherol is disclosed.

Document Details

Document Type
Technical Report
Publication Date
Aug 29, 1986
Accession Number
ADD012484

Entities

People

  • Martha C. Farmer
  • Richard L. Beissinger

Organizations

  • United States Department of the Navy

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Biomolecules
  • Blood Substitutes
  • Blood Transfusions
  • Chemical Compounds
  • Chloroform
  • Cholesterol
  • Hemoglobin
  • Inventions
  • Payload
  • Pharmacologic Actions
  • Production
  • Synthetic Membranes
  • Vitamin E

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry