Effect of Dimethyl Sulfoxide on the Bactericidal Function of Polymorphonuclear Leukocytes,

Abstract

Dimethyl sulfoxide (DMSO) is now being widely used to treat various rheumatic, musculoskeletal, and inflammatory conditions, but the therapeutic and detrimental consequences of treating individuals with DMSO remain unclear. We have examined the possibility that DMSO might inhibit the bactericidal function of polymorphonuclear leukocytes (PMN) by scavenging hydroxyl radical (.OH), one of the key bactericidal components of PMN. Our results suggest that DMSO can decrease the ability of PMN to kill Staphylococcus aureus in vitro and that this inhibition may occur because DMSO scavenges .OH. These observations suggest that DMSO might impair PMN-mediated host defense.

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1983
Accession Number
ADP001824

Entities

People

  • Elaine M. Berger
  • John E. Repine
  • Richard B. Fox

Organizations

  • University of Colorado Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular System
  • Hydroxyl Radical
  • Inhibition
  • Leukocytes
  • Observation
  • Polymorphonuclear Leukocytes
  • Staphylococcus Aureus
  • Sulfur Compounds

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Microbial Pathology
  • Organic Chemistry