Studies on Biological Actions of Dimethyl Sulfoxide in Familial Amyloidosis,

Abstract

Dimethyl sulfoxide (DMSO) had not been regarded as a therapeutic drug against amyloidosis until 1974 when Osserman and Isobe administered it for the first time in six cases of primary amyloidosis. In 1973, we described an outline of the second largest concentration of familial amyloid polyneuropathy (FAP) cases which we discovered. We reported some tentative results of DMSO treatment in 18 cases. In this paper, we are presenting the effects of DMSO administration to patients with primary and familial amyloidosis from both clinical and biochemical viewpoints and in vitro effects of DMSO on extracted amyloid fibril proteins.

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1983
Accession Number
ADP001831

Entities

People

  • Eiko Itoga
  • Masae Inokawa
  • Masatoshi Hironaka
  • Shozo Kito
  • Takenobu Kishida

Organizations

  • Hiroshima University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemical Compounds
  • Diseases And Disorders
  • Metabolic Diseases
  • Neuromuscular Diseases
  • Sulfur Compounds

Fields of Study

  • Medicine

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