Dimethyl Sulfoxide Inhibition of Prostacyclin Production in Cultured Aortic Endothelial Cells,
Abstract
Prostaglandin metabolism is significantly altered in advanced atherosclerosis, resulting in an increased platelet aggregation and adhesiveness. Inhibition of prostacyclin (PGI) biosynthesis by arterial endothelial cells and stimulation of thromboxane A by; platelets has been observed in experimentally induced atherosclerosis in; animals. Dimethyl sulfoxide (DMSO) has been reported to impair platelet aggregation and to inhibit PGE and PGF synthesis in seminal vesicle microsomes in vitro. Because of these reports we have investigated the effect of DMSO and its major metabolite, dimethyl sulfone on the synthesis of PGI by cultured endothelial cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1983
- Accession Number
- ADP001858
Entities
People
- Don L. Layman
- Syed S. Alam
Organizations
- Oregon Health & Science University