The Effect of Dimethyl Sulfoxide on Endotoxin-Induced Pulmonary Dysfunction: A Biochemical and Electron Microscope Study

Abstract

The results of this study indicate that DMSO has a significant effect in preserving PCEC luminal ATPase activity and fine structure and survival in endotoxin-treated rats. Although the exact mechanisms remain speculative, data from this study and others suggest that the effect may involve the inhibition of the release of lysosomal enzymes and the scavenging of O2 metabolites, such as superoxide anion (.O2(-)), hydrogen peroxide (H2O2), and hydroxyl radicals (.OH) , produced by endotoxin-stimulated phagocytes. Most organisms have active enzymes for catabolism of H2O2 and .o2(-) (precursors of .OH). However, there are no direct enzymatic mechanisms for the clearance of the highly cytotoxic . OH. Thus, the reaction of DMSO with .OH may be an explanation for the protective mechanism.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1983
Accession Number
ADP001860

Entities

People

  • Marvin W. Harrison
  • Reid S. Connell
  • Roy E. Breen

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Blood
  • Cells
  • Dysfunction
  • Electron Microscopes
  • Electrons
  • Elements
  • Endothelial Cells
  • Endotoxins
  • Free Radicals
  • Hydrogen
  • Hydroxyl Radical
  • Laboratory Animals
  • Materials
  • Rocket Oxidizers
  • Sulfur Compounds

Readers

  • Cardiovascular Physiology
  • Immunology
  • Prostate Cancer Biology.

Technology Areas

  • Microelectronics