The Effects of Chronic DMSO (Dimethyl Sulfoxide) Administration on the Spontaneous Development of Autoimmune Disease in NZB, BXSB, and MRL/LPR Strain Mice,
Abstract
In conclusion, chronic DMSO injections did not retard or accelerate the pathogenesis of autoimmune-lymphoproliferative disease in three genetically distinct mouse models of systemic lupus. This result is consistent with observations described in our accompanying study, which showed no effect of DMSO injections on primary IgM or secondary IgM plus IgG antibody plague-forming cell responses after sheep erythrocyte immunization. Nor was any change in natural killer cell activity observed. It remains possible that other doses, routes, or regimens of DMSO treatment might influence disease pathogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1983
- Accession Number
- ADP001865
Entities
People
- B. V. Siegel
- J. I. Morton
- S. W. Jacob
- T. Bristol
- W. J. Weaver
Organizations
- Oregon Health & Science University