Improvement in Somatosensory Evoked Response Amplitude and Neurologic Function Following DMSO (Dimethyl Sulfoxide) in a Cat Model of Chronic Spinal Cord Compression,

Abstract

Beginning at approximately five minutes after administration of intravenous DMSO, the evoked response amplitude increased rapidly. This increase was most striking in the second five minutes after administration, by which time the amplitude of the early components had increased by an average of 175%. A slow increase continued over the next 35 minutes, at which time the response seemed to plateau at about 225% of the control value. When the animals were examined following intraperitoneal DMSO the next day, the results were mixed. All animals were unable to stand at this time. Three animals showed no improvement after DMSO. Three animals were able to stand but not walk. Two were able to ambulate unsteadily. The improvements in function lasted from five to six hours, following which the animals returned to their pre-DMSO state and were sacrificed.

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1983
Accession Number
ADP001868

Entities

People

  • J. E. Mccallum

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amplitude
  • Anatomy
  • Biological Sciences
  • Central Nervous System
  • Compression
  • Spinal Cord
  • Sulfur Compounds

Fields of Study

  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology