Dimethyl Sulfoxide and the Calcium Paradox,
Abstract
The results indicate that DMSO does not protect rat hearts against the effects of calcium-free perfusion that predispose the myocardium to the calcium paradox. The calcium-paradox damage is reduced, however, when DMSO is present during the reperfusion phase. The reduction of the calcium paradox damage may be affected by the hyperosmolarity of the DMSO-containing reperfusion medium, reduction by DMSO of the energy-dependent accumulation of calcium by mitochondria, which can lead to severe cell damage, and enhancement of the calcium-accumulating ability of the sarcoplasmic reticulum, resulting in a decreased supply of calcium to the mitochondria during the reperfusion phase.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1983
- Accession Number
- ADP001871
Entities
People
- A. M. Slade
- D. De Moes
- T. J. C. Ruigrok
- W. G. Nayler