The Use of Tumor Models in Immunotoxicity Testing
Abstract
The role of the immune system in the prevention and control of tumor growth has been a rapidly expanding area of research during the past decade. The concept that a host could immunologically recognize and thus eliminate transformed cells from the body offered many new prospects for the prevention and treatment of cancer. From a toxicology standpoint, however, immunologic control of tumor growth presented an additional area for concern - that is, that even if a chemical was not directly carcinogenic, it might, through effects on the immune system, create an individual that was more susceptible to tumor growth, and thus present an even more subtle hazard than a direct carcinogen. Because of the biologic and toxicologic relevance of a tumor model, our laboratory has been working to develop suitable tumor models for use in immunotoxicity testing. In addition to the toxicologic significance of altered tumor susceptibility due to chemical exposure, a tumor model could also provide several testing advantages from a technical standpoint.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADP001966
Entities
People
- Nancy I. Kerkvliet
Organizations
- Oregon State University