Uptake and Fate of Inhaled Particles and Gases: The Importance of Species Differences
Abstract
This paper discusses the problem of interpreting animal experiments to better predict the potential of an agent to cause damage in humans. Although many species have been used to assess the toxicity of chemicals, and although species differences are both recognized and argued about, we lack a complete and systematic description of the differences among commonly used laboratory animals. The subspecialty of inhalation toxicology is no exception. It is difficult to abstract a comprehensive description of species differences from the literature because so many different kinds of animals and aerosols have been used in various combinations. Several theoretical and experimental contributions exist, but the problem is far from solved. Three aspects of exposure to toxic particles and gases are considered. They are: deposition, clearance, and the magnitude and type of biological response.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADP001972
Entities
People
- George A. Mensah
- Joseph D. Brain
Organizations
- Harvard T.H. Chan School of Public Health