The Cytosol Receptor for 2,3,7,8-Tetrachlorodibenzo-P-Dioxin: Mediator of Two Distinctive Pleiotropic Responses,

Abstract

This report discusses two experimental systems as models for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) toxicity: a) the response of the epidermis in HRS/J mice and b) the keratinization of mouse teratoma cell line XB. Each system illustrates the two distinctive pleiotropic responses to the halogenated aromatic hydrocarbons controlled by the cytosol receptor: the one primarily concerned with the induction of drug metabolizing enzymes; the other, a more extensive response, involving differentiation. From these data, we suggest a model which may provide a general framework in which to consider the tissue specific and species specific toxicity of the halogenated aromatic hydrocarbons.

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1983
Accession Number
ADP001976

Entities

People

  • Alan Poland
  • Joyce C. Knutson

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Biological Sciences
  • Cell Line
  • Cells
  • Chemical Compounds
  • Cyclic Hydrocarbons
  • Ecotoxicology
  • Epidermis
  • Hydrocarbons
  • Keratinization
  • Organic Compounds
  • Tissues
  • Toxicity
  • Toxicology

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