Receptors for 2,3,7,8-Tetrachlorodibenzo-P-Dioxin: Their Inter- and Intra-Species Distribution and Relationship to the Toxicity of this Compound,
Abstract
Since the 1950's, the chlorinated dibenzo-p-dioxins and related compounds, including the halogenated biphenyls, dibenzofurans, as well as azo- and azoxy-benzenes, have received considerable attention as toxic environmental contaminants. This has been due primarily to numerous accidental poisonings of human and animal populations (Kimbrough, 1974; Poland and Kende, 1976; Regiani, 1980) as well as their extreme toxic potency observed in a variety of laboratory animals (Schwetz et al., 1973). Recently, studies by Pitot and co-workers (1980) suggest 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to be an extremely potent tumor promoting agent. These and related studies have motivated additional interest in this class of compounds as molecular and biochemical probes. In spite of much research, the exact biochemical mechanism(s) of this class of compound remain(s) as yet unknown. However, evidence accumulated within the past six years suggests the toxicity of these compounds is mediated through specific binding to a cytosolic protein or receptor molecule.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADP001978
Entities
People
- Thomas A. Gasiewicz
Organizations
- University of Rochester