Toxicity and Carcinogenicity of Polybrominated Biphenyls,
Abstract
The different Polybrominated Biphenyls (PBB) congeners are in fact very different chemicals with different biological responses. Some are metabolized by liver microsomal enzymes which are induced by phenobarbital. Some are metabolized by enzymes induced by 3-MC. Some of the PBB congeners induce enzymes which are induced by phenobarbital, some induce enzymes induced by 3-MC, and some induce both types of enzymes. The congeners which induce these enzymes aren't necessarily metabolized. The toxic congeners must be able to exist in a planar configuration, apparently in order to serve as a ligand for the TCDD receptor, because toxicity is well correlated with the induction of AHH activity. Both toxic and non-toxic congeners appear to promote the development of enzyme altered foci in rats treated with diethylnitrosamine. Promotion by a toxic congener does not seem to be correlated with liver microsomal enzyme induction but appears related to pathology. The toxic and non-toxic congeners do not appear to be promoters in the same dose range, and perhaps not by the same mechanisms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADP001979
Entities
People
- James E. Trosko
- Steven D. Aust
- Stuart D. Sleight
Organizations
- Michigan State University