Effect of 2,5-Hexanedione on Testicular Morphology and Biochemistry,
Abstract
N-Hexane is one of a family of hexacarbons which are neurotoxicants in both humans (Yamamura, 1969) and experimental animals (Shaumburg & Spencer, 1976). The severity of the neurotoxicity has been found to be proportional to the amount of a metabolite of hexane, 2,5-hexanedione (2,5-HD) , produced in vivo (Krasavage et al., 1980). Oral administration of 2,5-HD will produce peripheral neuropathy (Couri & Nachtman, 1979) and testicular degeneration (Krasavage et al., 1980) similar to that seen after n-hexane treatment of laboratory animals. A previously well-characterized drinking water model of 2,5-HD administration was used to examine the testicular lesion seen in rats after 2,5-HD consumption.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADP001986
Entities
People
- Robert E. Chapin
Organizations
- National Institute of Environmental Health Sciences