High to Low Dose Extrapolation of Experimental Animal Carcinogenesis Studies,
Abstract
Quantitative risk assessment requires extrapolation from results of experimental assays conducted at high dose levels to predicted effects at lower dose levels which correspond to human exposures. The meaning of this high to low dose extrapolation within an animal species will be discussed, along with its inherent limitations. A number of commonly used mathematical models of dose-response necessary for this extrapolation, will be discussed. Other limitations in their ability to provide precise quantitative low dose risk estimates will also be discussed. These include: the existence of thresholds; incorporation of background, or spontaneous responses; modification of the dose-response by pharmacokinetic processes. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1984
- Accession Number
- ADP003856
Entities
People
- C. C. Brown
Organizations
- National Cancer Institute