Prevention of Ischemia-Induced Acute Renal Failure,
Abstract
Mannitol, furosemide, prostaglandin E2, and verapamil have been demonstrated to be protective against ischemic acute renal failure. Although the functional improvements in such renal parameters as glomerular filtration rate and tubular reabsorption of sodium are clearly demonstrable after therapy, the cellular mechanism(s) that underlie the decreased renal function are not well understood. These pharmacological agents exert multiple physiological effects, and it has been difficult to attribute their protective effect(s) to a common mechanism. However, new insights into the protective role of each of these drugs have been derived from our sequential studies of mitochondrial function during and following ischemia in both the intrarenal norepinephrine model (NE; 0.75 mg/kg/min) and the renal artery clamp model (45-50 min) of ischemic acute renal failure (ARF) in dog and rat, respectively.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 29, 1983
- Accession Number
- ADP003865
Entities
People
- P. E. Arnold
- R. W. Schrier
- T. J. Burke
Organizations
- University of Colorado Boulder