The Role of the Macrophage in the Host Response to Bacterial Endotoxins

Abstract

Unique to Gram-negative bacilli is the presence of a complex glycolipid in the outer cell membrane. This component, termed endotoxin or lipopolysaccharide (LPS), is now generally recognized as the bacterial product that is responsible for initiating the biochemical changes leading to shock, DIC, and death. The purpose of this report is to describe a number of mediators produced by LPS-treated macrophages that may participate in the host response to LPS, namely, a supernatant factor of LPS-treated macrophage (M), which suppresses adrenocortical steroidogenesis, and a membrane-bound procoagulant activity, which activates coagulation Factor X directly.

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Document Details

Document Type
Technical Report
Publication Date
Apr 29, 1983
Accession Number
ADP003868

Entities

People

  • J. C. Mathison
  • P. S. Tobias
  • R. J. Ulevitch

Organizations

  • Scripps Research

Tags

DTIC Thesaurus Topics

  • Blood Coagulation Factors
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Electron Microscopy
  • Endoplasmic Reticulum
  • Endotoxic Shock
  • Infection
  • Macrophages
  • Membranes
  • Nervous System
  • Neurosecretory Systems
  • Shock (Pathology)
  • Tissues

Fields of Study

  • Medicine

Readers

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