Canine Hematopoiesis in a Model of Combined Injury

Abstract

The development of a large animal model for CI within the context of a nuclear disaster required that we describe, experimentally, the essential features of the radiobiology of acute effects in the canine. The large-animal model is also appropriate for assessing the immunologic, pharmacologic, and surgical modes of intervention of following CI. The canine model of CI at the AFRRI has stressed three developmental aspects: (a) establishing the radiobiology of the canine hemopoietic system, (b) choosing a relevant model for peritoneal sepsis, and (c) identifying several choices for physical trauma. This paper stresses the relevance of the first aspect, the radiation-induced suppression and recovery of the hemopoietic system.

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Document Details

Document Type
Technical Report
Publication Date
Apr 29, 1983
Accession Number
ADP003869

Entities

People

  • D. F. Gruber
  • M. Fink
  • M. L. Patchen
  • R. L. Monroy
  • T. J. Macvittie

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Coagulation
  • Burns
  • Cardiovascular System
  • Cells
  • Cellular Structures
  • Fission Neutrons
  • Gamma Rays
  • Ionization Chambers
  • Ionizing Radiation
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Stem Cells
  • Therapy

Fields of Study

  • Medicine

Readers

  • Immunology
  • Nuclear and Radiation Engineering.
  • Systems Analysis and Design