Molecular Mechanisms of n-Hexane Neurotoxicity,
Abstract
A hypothetical molecular mechanism of action must ideally account for the structure/activity relationships, neurofilament accumulation, in vivo covalent protein binding, direct action on axonal components, and target organ specificity which are characteristic of the neuropathy caused by these compounds. Although this ideal has not yet been realized, substantial progress has been made toward elucidation of the crucial events leading to neuropathy. Ultimate success awaits exploration of the molecular interaction of the neurotoxic diketones with axonal components in vivo. The distinguishing features of n-hexane neuropathy are listed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1984
- Accession Number
- ADP004020
Entities
People
- A. P. Decaprio
Organizations
- New York State Department of Health