Effect of Injury or Resuscitation on Coagulation Mechanisms,
Abstract
In order to determine if products of fibrinolysis alter filtration or permeability, exogenous (purified Fragments D and E) products, and plasmin were tested in an isolated, autoperfused catileum preparation. Steady-state lymphatic and plasma protein concentration ratio (C sub L/C sub P) and lymph flows (Q sub L) were measured at a venous outflow pressure of 0 mmHg. Data was analyzed for each animal group by the paired Student test for Q sub L, C sub L/C sub P, and protein clearance (Q sub L x C sub L/C sub P). In cats which received Fragment D (n=7), Q sub L and clearance increased five-fold (P < 0.002), but C sub L/C sub P) was not altered, which suggests a permeability change. Ileal mucosa wa depithelialized and blood vessels were damaged. Fragment E (n=7) provoked a slight increase in Q sub L (P<0.01), but not in C sub L/P E sub L or clearance. Histology was normal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 21, 1983
- Accession Number
- ADP004406
Entities
People
- D. Manwaring
- N. Granger
- P. W. Curreri
Organizations
- University of South Alabama