Pharmacologic Intervention in Shock,

Abstract

A scheme of the progressive changes that occur with shock and ischemia which we have previously discussed in detail is presented in Figure 1. The major changes during such conditions are in microcirculation, cell membrane transport and function, energy metabolism and mitochondrial function. These progressive and interrelated events eventually lead to cell swelling. Studies showed that infusion of ATP-MgCl2 (along with volume restitution) following hemorrhagic shock and sepsis-peritonitis in animals proved beneficial for survival.

Document Details

Document Type
Technical Report
Publication Date
Jan 21, 1983
Accession Number
ADP004408

Entities

People

  • A. E. Baue
  • I. H. Chaudry

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Cell Membrane
  • Cells
  • Hemorrhagic Shock
  • Infusions
  • Intervention
  • Ischemia
  • Membranes
  • Memory Devices
  • Metabolism
  • Pathologic Processes
  • Survival
  • Transport Ships

Readers

  • Cardiovascular Physiology
  • Systems Analysis and Design