Bacterial Resistance to Topical Agents,
Abstract
Sulfonamide resistance was greater than 78% in gram-negative organisms isolated during the last 12 months. This is a continuation of our previous experience. Sulfadiazine (SD) in silver-sulfadiazine (AgSD) is the only bacteriologically active sulfonamide used on our burn ward. We investigated the requirement of sulfadiazine for the in vitro activity of silver-sulfadiazine. A bacteriologically inactive analog of sulfadiazine was synthesized. The structure of sodium salts of sulfadiazine and the synthesized analog benzenesulfonamidopyrimidine (ISR-44) are presented in Figure 1. As can be seen, the two structures are very similar except that the analog does not have the N-4 amino group (para-amino) necessary for paraminobenzoic acid antagonism. The silver salts of sulfadiazine and its analog were prepared. The two sodium salts and the two silver salts were then examined for in vitro and in vivo (burned rat) activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 21, 1983
- Accession Number
- ADP004411
Entities
People
- A. T. Mcmanus
Organizations
- United States Army Institute of Surgical Research