Chemical Interactions in Complex Atmospheres and the Effect on Uptake of Individual Components by the Lung
Abstract
The fraction of an inhaled toxic compound which penetrates the upper airways to the lung parenchyma will constitute the biologically effective dose; this dose can be altered by several phenomena. The principles involved have been reasonably well documented for particulate matter and for individual gases and vapors. Relatively complex gas, vapor, and particle mixtures are, however, more difficult to characterize. Among the likely processes which might alter the magnitude or site of deposition are the alteration of particle size, changes in the aerodynamic properties of the airways themselves, adsorptive phenomena that allow otherwise easily removed gases or vapors to penetrate more deeply within the respiratory tract, and the formation of new, labile (but potent) toxic agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1985
- Accession Number
- ADP005139
Entities
People
- Michael T. Kleinman
Organizations
- University of California, Irvine