Report of the Subpanel on Short Term Tests of the Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation to the National Toxicology Program Board of Scientific Advisors: A Summary,

Abstract

The Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation prepared a report recommending to the National Toxicology Board of Scientific Counselors methods that NTP should use to detect and evaluate chemical carcinogens. The Ad Hoc Panel consisted of three subpanels: the first dealing with short term tests, the second with subchronic studies, and the third with chronic studies. The first subpanel reviewed the advantages/disadvantages and correlation data for short term tests in general. The NTP short term testing program involved: Salmonella Typhimurium, L5178Y Lymphoma (TK+/-Forward Mutation Assay); Chromosome Aberration and Sister Chromatid Exchange (SCE) - Chinese Hamster Ovary In Vitro; Unscheduled DNA Synthesis (UDS) - Rat Hepatocyte (Rat Liver Primary Cell Culture Assay); Cell Transformation.

Document Details

Document Type
Technical Report
Publication Date
May 01, 1985
Accession Number
ADP005143

Entities

People

  • Frederica P. Perera

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Carcinogens
  • Cells
  • Chromosome Aberrations
  • Chromosome Structures
  • Chromosomes
  • Culture Techniques
  • Ecotoxicology
  • Epithelial Cells
  • Genetic Phenomena
  • Mutations
  • Test And Evaluation
  • Toxicology

Readers

  • Naval Engineering and Maritime Security
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology